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Funding This study was funded by the Universidad Veracruzana through Interdisciplinary Research Award 20192020 to OV

Notably, excess hemin exposure exacerbates the disease severity of SCD 19,20 and heme-scavenging strategies such as intravenous infusion of hemopexin are propective 21,22

GHK-Cu is a copper-bound peptide that has garnered significant attention due to its collagen-stimulating properties

In this paper, we explore the potential role of certain amyloidogenic proteins, including amylin, amyloid beta, the prion protein, huntingtin, and -synuclein, in disease processes that result in the accumulation of deposits of protein fibrils, along with lipid membrane components of damaged mitochondria, which we argue may be a mechanism to sequester deuterium in order to reduce the deuterium burden in the tissues

Topical GHK-Cu is a local intervention: the copper tripeptide is placed directly against the tissue it is meant to influence, and only a limited fraction reaches deeper layers or the systemic circulation

Thus, arginine-mediated induction of mTOR seems to restrict Treg cells function and promote CD8 + T cells antitumor immunity [83]